Biotherapies & Immunology (CIC-BTi)

Clinical Investigation Center


​The Clinical Investigation Center in Biotherapy and Immunology has a unique expertise in translational research in immunology. The CIC-BTi offers support to investigators to perform clinical studies - from cognitive to therapeutic studies - in the fields of Biotherapies and Immunology.

The CIC-BTi offers technical, logistic and administrative support to investigators. This includes:
  • ​​An overall assessment of the project to establish clinical development plans,
  • The design of protocols and associated methodological aspects,
  • The design of biological monitoring and when necessary the development of specific tests,
  • The GMP production of cell populations, with or without genetic modifications,  
  • The dealing with all regulatory and administrative aspects.
Previous contributions: The CIC-BTi has contributed to the clinical development of new approaches of T cell manipulations in the field of bone marrow transplantation. We notably reported that the depletion of Treg in donor lymphocytes infusion (DLI) after leukemia relapse post allogeneic hematopoietic stem cell transplantation improves the alloreactivity of the DLI and its therapeutic efficacy. We have also pioneered the clinical use of low-dose IL-2 as a safe Treg inducer in autoimmune and autoinflammatory diseases. ​

Fields of interest

Regulatory and methodology aspects of biotherapies’ development, Complex immunomonitoring, Treg and IL-2 clinical trials


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Contact info

Address: Hôpital Pitié-Salpêtrière CIC-BTi, Biothérapie, 83 boulevard de l’Hôpital
City: Paris
Postal code: 75651
Telephone: +33 1 42 17 74 73
Fax: +33 1 42 17 74 62

Top Publications

Cognitive Clinical Investigations