Immune system, Neuroinflammation and Neurodegenerative diseases (IN2)
description
The IN2 laboratory has long been interested in the involvement of adaptive immune responses in prion diseases, and more recently in Alzheimer's disease.
Our main current research topics are the following :
- Studies of CD4+ T cell responses in mouse experimental models of AD, including construction of TCR-transgenic lines as sources of naive cells specific for amyloid-beta peptide and Tau protein.
- Human clinical studies: A project supported by Roche and AP-HP, coordinated by Marie Sarazin, is aimed at identifying immune biomarkers at early stages of Alzheimer's disease (mild cognitive impairment). Another french collaborative project is based on fine analyses of antibodies specific for pathogenic misfolded proteins.
Fields of interest
Alzheimer’s disease, mouse models, cognitive functions, adaptive immunity, CD4+ T cells, TCR-transgenic, regulatory T cells, neuroinflammation, antibody
Affiliations
Contact info
Address: IN2 Immune system, neuroinflammation and neurodegenerative diseases, Hôpital Saint-Antoine, Bâtiment Kourilsky, 5th floor, 184 rue du Faubourg Saint-AntoineCity: Paris
Postal code: 75571
Telephone: + 33 1 49 28 46 70
Fax: +33 (0)1 43 40 17 48
Email: keila.risal@inserm.fr
Top Publications
- Sarazin M, Dorothée G, de Souza LC, Aucouturier P
Immunotherapy in Alzheimer's disease: do we have all the pieces of the puzzle?
Biol Psychiatry 74, 329-332 (2013) - Dorothée G, Bottlaender M, Moukari E, de Souza LC, Maroy R, Corlier F, Colliot O, Chupin M, Lamari F, Lehéricy S, Dubois B, Sarazin M, Aucouturier P
Distinct patterns of antiamyloid-β antibodies in typical and atypical Alzheimer disease
Arch Neurol 69, 1181-115 (2012) - Toly-Ndour C, Lui G, Nunes MM, Bruley-Rosset M, Aucouturier P, Dorothée G
MHC-independent genetic factors control the magnitude of CD4+ T cell responses to amyloid-β peptide in mice through regulatory T cell-mediated inhibition
J Immunol 187, 4492-4500 (2011) - Iken S, Bachy V, Gourdain P, Lim A, Gregoire S, Chaigneau T, Aucouturier P, Carnaud C.
Th2-polarised PrP-specific transgenic T-cells confer protection against murine scrapie.
PLoS Pathogens 7, e1002216 (2011)