Commensal and Probiotics-Host Interactions (ProbiHote)



Our team focus is in the areas of a better knowledge of the crosstalk between host and resident and transiting microbiota in physiological and patho-physiological conditions. They should lead to an optimized use of commensal and probiotic bacteria in human and animal health. We also study the mechanisms involved in the complex crosstalk between the gut microbiota and the host in health, and its alterations leading to human diseases such as Inflammatory Bowel Diseases (IBD), Irritable Bowel Syndrome (IBS), Short bowel Syndrome (SBS).

Our team has acquired an international recognition and is considered as leader in the following scientific fields involving the crosstalk host-bacteria

- health-related effects of commensal and probiotic bacteria

- use of recombinant lactic acid bacteria to deliver molecules of health interest

- impact of microbiota on digestive physiology

Organization :

Our team is composed by 35 persons and organized in 4 complementary groups : i) Probiotics, commensals and inflammation (PI: L. Bermudez-Humaran); ii) Host Immuno-modulation (PI: JM Chatel) ; iii) Immunity and Host (PI: H. Sokol) ; iv) Relations microbiota-digestive epithelium (PI: M. Thomas)

Fields of interest

Lactic acid bacteria (LAB), Inflammation, Immunology, Probiotic bacteria, Inflammatory Bowel Disease (IBD), Cellular Models, Commensal bacteria, Cancer, Animal Models, Recombinant Bacteria, Obesity, Intestinal Microbiota, Microbiology


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Contact info

Address: INRA-Institut National de la Recherche Agronomique UMR 1319 MICALIS-Microbiologie de l'Alimentation au Service de la Santé humaine Domaine de Vilvert-Bât. 440 R-2
City: Jouy-en-Josas, France
Postal code: 78352
Telephone: +33 1 34 65 20 70
Fax: +33 (0) 1 34 65 24 62

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