Immunology - Immunopathology - Immunotherapy (i3)
description
i3 general objectives are to (i) advance the frontiers of knowledge in Immunology and (ii) develop novel immunotherapies, with a dual reductionist and systems biology approach. Within this translational systems immunology project, our focus is on tolerance in health and diseases.
To meet these objectives requires the interaction between people with very different skills: medical practitioners, biologists, computer scientists, project-managers… among others. Most of the research unit personnel and their specific skills contribute to a majority of our specific projects.
To meet these objectives requires the interaction between people with very different skills: medical practitioners, biologists, computer scientists, project-managers… among others. Most of the research unit personnel and their specific skills contribute to a majority of our specific projects.
i3 is organized in themes that we defined according to two different matrixes:
A matrix reflecting our global approaches covering
- health to disease
- mice to humans
- reductionism to systems biology
A matrix reflecting our global activities
- translational immunology
- immunotechnology
- systems biology
A matrix reflecting our global approaches covering
- health to disease
- mice to humans
- reductionism to systems biology
A matrix reflecting our global activities
- translational immunology
- immunotechnology
- systems biology
Based on these two matrixes, i3 is organized in three themes:
- Clinical immunology & Biotherapy (CiB)
- Experimental immunology & Biotherapy (EiB)
- Integrative immunology (i2)
- Clinical immunology & Biotherapy (CiB)
- Experimental immunology & Biotherapy (EiB)
- Integrative immunology (i2)
Importantly, these three themes stay closely related to multi-partner projects & structures that are true components of our global organization.
- i2B hospital/university department
- Transimmunom laboratory of excellence (LabEx)
- CIC-BTi - clinical investigation center in biotherapy and immunology
- i2B hospital/university department
- Transimmunom laboratory of excellence (LabEx)
- CIC-BTi - clinical investigation center in biotherapy and immunology
Affiliations
Contact info
Address: INSERM UMRS 959 - Sorbonne Université Bâtiment CERVI, CHU Pitié-Salpêtrière 83 boulevard de l'HôpitalCity: Paris
Postal code: 75013
Region: Île-de-France
Telephone: +33 1 42 17 74 61
Fax: +33 1 42 17 74 62
Email: i3.contact@transimmunom.org
Website: http://www.i3-immuno.fr
Top Publications
- Barennes P, Quiniou V, Shugay M, Egorov ES, Davydov AN, Chudakov DM, Uddin I, Ismail M, Oakes T, Chain B, Eugster A, Kashofer K, Rainer PP, Darko S, Ransier A, Douek DC, Klatzmann D, Mariotti-Ferrandiz E
Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Nature Biotechnology, 2020 - Chen T, Darrasse-Jèze G, Bergot AS, Courau T, Churlaud G, Valdivia K, Strominger JL, Ruocco MG, Chaouat G, Klatzmann D
Self-specific memory regulatory T cells protect embryos at implantation in mice
J Immunol. 191(5), 2273-2281 (2013) - Six A, Bellier B, Thomas-Vaslin V, Klatzmann D
Systems biology in vaccine design
Microb Biotechnol. 5(2), 295-304 (2012)