DHU:i2B

[event] - SCAIR

​2nd Meeting on Stochasticity and Control in Adaptive Immune Repertoires


Abstract 

Immuno-biology research is at a turning point. Novel experimental methods make possible imaging and molecular measurements in a high throughput fashion at the single cell and single molecule level. These methodologies are revolutionizing our picture of the nature of variability and control in biology in general and the immune system in particular. Novel theories are needed to catalyze our assimilation of these novel data. Building on our successful 2017 conference on Stochasticity and Control in Immune Repertoires at the Israeli Institute for Advanced Studies, we hope here to combine the latest cutting edge experimental and computational immunology results into a novel theoretical view on the complexity of immune function.  The adaptive immune system provides a robust defense against infection with pathogenic microorganisms while controlling against autoimmune disorders. Yet, many individual components of this system are based on stochastic (i.e., random) processes. B cell immunoglobulin and T cell receptors, which provide a critical recognition system for pathogens and self-antigens, are constructed by stochastic recombination of multiple possible genes. At the cell population level, single cells often have varied transcriptional, signaling and cytokine secretion responses to the same stimulus. How these random and diverse actions at the molecular level translate into robust action at the system level remains in question and will be the focus of our meeting. Understanding the changes of immune cell populations and how they reflect immune function is a key missing component in our ability to design vaccines and effective personalized medicine. We therefore hope from this meeting to both elevate our understanding of the complexity underlying immune adaptation and to advance the borders of clinical practice.


Date : from the 28th to the 31st October 2018


Place 

ISC-PIF, 113 rue Nationale
75013 Paris (France)


Registration closed



Sponsors

DIM biotherapie Ile de France, Sorbonne Universite, 10X genomics, Takarabio, Illumina


Organizing committee


Attachments